IUBMB Enzyme Nomenclature


Accepted name: N-sulfoglucosamine-3-sulfatase

Reaction: Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin

Other name(s): chondroitinsulfatase

Systematic name: N-sulfo-3-sulfoglucosamine 3-sulfohydrolase

Comments: The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Bruce, J.S., McLean, M.W., Long, W.F. and Williamson, F.B. Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate. Eur. J. Biochem. 148 (1985) 359-365. [PMID: 3987694]

2. Leder, I.G. A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-α-D-glucopyranoside 3-sulfate. Biochem. Biophys. Res. Commun. 94 (1980) 1183-1189. [PMID: 7396957]

[EC created 1984, modified 1989]

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