IUBMB Enzyme Nomenclature


Accepted name: steryl-sulfatase

Reaction: 3β-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3β-hydroxyandrost-5-en-17-one + sulfate

Other name(s): arylsulfatase; steroid sulfatase; sterol sulfatase; dehydroepiandrosterone sulfate sulfatase; arylsulfatase C; steroid 3-sulfatase; steroid sulfate sulfohydrolase; dehydroepiandrosterone sulfatase; pregnenolone sulfatase; phenolic steroid sulfatase; 3-β-hydroxysteroid sulfate sulfatase

Systematic name: steryl-sulfate sulfohydrolase

Comments: Also acts on some related steryl sulfates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9025-62-1


1. Roy, A.B. The steroid sulphatase of Patella vlugata. Biochim. Biophys. Acta 15 (1954) 300-301.

2. Roy, A.B. The synthesis and hydrolysis of sulfate esters. Adv. Enzymol. Relat. Subj. Biochem. 22 (1960) 205-235.

3. Stitch, S.R., Halkerston, I.D.K. and Hillman, J. The enzymic hydrolysis of steroid conjugates. 1. Sulphatase and β-glucuronidase activity of molluscan extracts. Biochem. J. 63 (1965) 705-710.

[EC created 1961]

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