IUBMB Enzyme Nomenclature


Accepted name: S-adenosyl-L-methionine hydrolase (adenosine-forming)

Reaction: S-adenosyl-L-methionine + H2O = adenosine + L-methionine

Other name(s): SAM hydroxide adenosyltransferase

Systematic name: S-adenosyl-L-methionine hydrolase (adenosine-forming)

Comments: The enzyme, found in bacteria and archaea, catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine. May be involved in regulating SAM levels in the cell. cf. EC, S-adenosyl-L-methionine hydrolase (L-homoserine-forming)

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Eustaquio, A.S., Harle, J., Noel, J.P. and Moore, B.S. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem 9 (2008) 2215-2219. [PMID: 18720493]

2. Deng, H., McMahon, S.A., Eustaquio, A.S., Moore, B.S., Naismith, J.H. and O'Hagan, D. Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). Chembiochem 10 (2009) 2455-2459. [PMID: 19739191]

[EC created 2018]

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