IUBMB Enzyme Nomenclature


Accepted name: S-adenosyl-L-methionine hydrolase (L-homoserine-forming)

Reaction: S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine

Glossary: S-methyl-L-methionine sulfonium salt = (S)-3-amino-3-carboxypropyldi(methyl)sulfonium salt

Other name(s): S-adenosylmethionine cleaving enzyme; methylmethionine-sulfonium-salt hydrolase; adenosylmethionine lyase; adenosylmethionine hydrolase; S-adenosylmethionine hydrolase; S-adenosyl-L-methionine hydrolase

Systematic name: S-adenosyl-L-methionine hydrolase (L-homoserine-forming)

Comments: Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC, (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Mazelis, M., Levin, B. and Mallinson, N. Decomposition of methyl methionine sulfonium salts by a bacterial enzyme. Biochim. Biophys. Acta 105 (1965) 106-114. [PMID: 5849106]

[EC created 1972 as EC, modified 1976, modified 2018, transferred 2022 to EC]

Return to EC 3.13.2 home page
Return to EC 3.13 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page