IUBMB Enzyme Nomenclature


Accepted name: blood-group-substance endo-1,4-β-galactosidase

Reaction: Endohydrolysis of (1→4)-β-D-galactosidic linkages in blood group A and B substances

Other name(s): endo-β-galactosidase (ambiguous); blood-group-substance 1,4-β-D-galactanohydrolase

Systematic name: blood-group-substance 4-β-D-galactanohydrolase

Comments: Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to a 1,3-α-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-α-D-fucosyl residue.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 52720-51-1


1. Fukuda, M.N. and Matsumara, G. Endo-β-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein. J. Biol. Chem. 251 (1976) 6218-6225. [PMID: 135762]

2. Nakazawa, K. and Suzuki, S. Purification of keratan sulfate-endogalactosidase and its action on keratan sulfates of different origin. J. Biol. Chem. 250 (1975) 912-917. [PMID: 234443]

3. Takasaki, S. and Kobata, A. Purification and characterization of an endo-β-galactosidase produced by Diplococcus pneumoniae. J. Biol. Chem. 251 (1976) 3603-3609. [PMID: 6459]

[EC created 1984]

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