IUBMB Enzyme Nomenclature


Accepted name: 1,6-α-D-mannosidase

Reaction: Hydrolysis of the 1,6-linked α-D-mannose residues in α-D-Manp-(1→6)-D-Manp

Systematic name: 1,6-α-mannosyl α-D-mannohydrolase

Comments: The enzyme is specific for (1→6)-linked mannobiose and has no activity towards any other linkages, or towards p-nitrophenyl-α-D-mannopyranoside or baker's yeast mannan. It is strongly inhibited by Mn2+ but does not require Ca2+ or any other metal cofactor for activity.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Athanasopoulos, V.I., Niranjan, K. and Rastall, R.A. The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis. Carbohydr. Res. 340 (2005) 609-617. [PMID: 15721331]

[EC created 2007]

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