IUBMB Enzyme Nomenclature


Accepted name: carboxymethylcellulase

Reaction: Endohydrolysis of (1→4)-β-D-glucosidic linkages in (carboxymethyl)cellulose.

Other name(s): CMCase

Systematic name: 4-β-D-(carboxymethyl)glucan 4-(carboxymethyl)glucanohydrolase

Comments: The enzyme from the acidophilic bacterium Alicyclobacillus acidocaldarius is an endo-cleaving hydrolase that cleaves β(1→4)-linked residues. However, it is specific for (carboxymethyl)cellulose and does not act on cellulosic substrates such as avicel.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9055-57-6


1. Morana, A., Esposito, A., Maurelli, L., Ruggiero, G., Ionata, E., Rossi, M. and La Cara, F. A novel thermoacidophilic cellulase from Alicyclobacillus acidocaldarius. Protein Pept. Lett. 15 (2008) 1017-1021. [PMID: 18991780]

[EC created 2017]

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