IUBMB Enzyme Nomenclature


Accepted name: glucosylglycerate hydrolase

Reaction: 2-O-(α-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate

Other name(s): GG hydrolase; GgH

Systematic name: 2-O-(α-D-glucopyranosyl)-D-glycerate D-glucohydrolase

Comments: The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(α-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Alarico, S., Costa, M., Sousa, M.S., Maranha, A., Lourenco, E.C., Faria, T.Q., Ventura, M.R. and Empadinhas, N. Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate. Sci Rep 4 (2014) 6766. [PMID: 25341489]

2. Cereija, T.B., Alarico, S., Empadinhas, N. and Pereira, P.JB. Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase. Acta Crystallogr. F Struct. Biol. Commun. 73 (2017) 536-540. [PMID: 28876234]

[EC created 2018]

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