IUBMB Enzyme Nomenclature


Accepted name: α-mannosidase

Reaction: Hydrolysis of terminal, non-reducing α-D-mannose residues in α-D-mannosides

Systematic name: α-D-mannoside mannohydrolase

Other name(s): α-D-mannosidase; p-nitrophenyl-α-mannosidase; α-D-mannopyranosidase; 1,2-α-mannosidase; 1,2-α-D-mannosidase; exo-α-mannosidase

Comments: Also hydrolyses α-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9025-42-7


1. Li, Y.-T. Presence of α-D-mannosidic linkage in glycoproteins. Liberation of D-mannose from various glycoproteins by α-mannosidase isolated from jack bean meal. J. Biol. Chem. 241 (1966) 1010-1012.

2. Winchester, B. Role of α-D-mannosidases in the biosynthesis and catabolism of glycoproteins. Biochem. Soc. Trans. 12 (1984) 522-524. [PMID: 6428944]

[EC created 1961]

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