IUBMB Enzyme Nomenclature


Accepted name: hyaluronoglucuronidase

Reaction: Random hydrolysis of (1→3)-linkages between β-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate

Other name(s): hyaluronidase; glucuronoglucosaminoglycan hyaluronate lyase; orgelase

Systematic name: hyaluronate 3-glycanohydrolase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37288-34-9


1. Linker, A., Meyer, K. and Hoffman, P. The production of hyaluronate oligosaccharides by leech hyaluronidase and alkali. J. Biol. Chem. 235 (1960) 924-927.

2. Meyer, K., Hoffman, P. and Linker, A. Hyaluronidases, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 4, Academic Press, New York, 1960, pp. 447-460.

[EC created 1965, modified 1980]

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