IUBMB Enzyme Nomenclature


Accepted name: glycosylceramidase

Reaction: a glycosyl-N-acylsphingosine + H2O = an N-acylsphingosine + a sugar

Other name(s): phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase

For diagram of the reaction click here or click here.

Systematic name: glycosyl-N-acylsphingosine glycohydrolase

Comments: Broad specificity [cf. EC (glucosylceramidase) and EC (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC lactase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9033-10-7


1. Leese, H.J. and Semenza, G. On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. J. Biol. Chem. 248 (1973) 8170-8173. [PMID: 4752949]

2. Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase. Eur. J. Clin. Invest. 2 (1972) 326-331. [PMID: 5082068]

3. Malathi, P. and Crane, R.K. Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane. Biochim. Biophys. Acta 173 (1969) 245-256. [PMID: 5774775]

[EC created 1972, modified 1976]

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