Reaction: nicotinamide β-D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide
Other name(s): NMNase; nicotinamide mononucleotide nucleosidase; nicotinamide mononucleotidase; NMN glycohydrolase; NMNGhase
Systematic name: nicotinamide-nucleotide phosphoribohydrolase
Comments: The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37237-49-3
References:
1. Andreoli, A.J., Okita, T.W., Bloom, R. and Grover, T.A. The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli. Biochem. Biophys. Res. Commun. 49 (1972) 264-269. [PMID: 4342726]
2. Imai, T. Isolation and properties of a glycohydrolase specific for nicotinamide mononucleotide from Azotobacter vinelandii. J. Biochem. 85 (1979) 887–899. [PMID: 457634]
3. Imai, T. Properties of allosteric nicotinamide mononucleotide glycohydrolase from Azotobacter vinelandii: activation and inhibition. J. Biochem. 101 (1987) 163–173. [PMID: 3571198]