IUBMB Enzyme Nomenclature


Accepted name: rRNA N-glycosylase

Reaction: Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes

Other name(s): ribosomal ribonucleate N-glycosidase; nigrin b; RNA N-glycosidase; ricin; momorcochin-S; Mirabilis antiviral protein; momorcochin-S; gelonin; saporins; rRNA N-glycosidase

Systematic name: rRNA N-glycohydrolase

Comments: Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 113756-12-0


1. Endo, Y. and Tsurugi, K. The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. J. Biol. Chem. 263 (1988) 8735-8739. [PMID: 3288622]

[EC created 1990, modified 2000]

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