IUBMB Enzyme Nomenclature


Accepted name: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase

Reaction: (2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate

For diagram of reaction click here.

Glossary: (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate = trans-2,3-dihydro-3-hydroxyanthranilate

Other name(s): isochorismatase (ambiguous); phzD (gene name)

Systematic name: (2S)-2-amino-4-deoxychorismate pyruvate-hydrolase

Comments: Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Mavrodi, D.V., Bonsall, R.F., Delaney, S.M., Soule, M.J., Phillips, G. and Thomashow, L.S. Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J. Bacteriol. 183 (2001) 6454-6465. [PMID: 11591691]

2. Parsons, J.F., Calabrese, K., Eisenstein, E. and Ladner, J.E. Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway. Biochemistry 42 (2003) 5684-5693. [PMID: 12741825]

[EC created 2016]

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