IUBMB Enzyme Nomenclature


Accepted name: limonene-1,2-epoxide hydrolase

Reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol

For diagram of reaction click here.

limonene = mentha-1,8-diene
limonene-1,2-epoxide = 1,2-epoxymenth-8-ene
limonene-1,2-diol = menth-8-ene-1,2-diol

Other name(s): limonene oxide hydrolase

Systematic name: limonene-1,2-epoxide hydrolase

Comment: Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. Enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC (trans-epoxysuccinate hydrolase), EC (leukotriene-A4 hydrolase), EC (hepoxilin-epoxide hydrolase), EC (microsomal epoxide hydrolase) and EC (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 216503-88-7


1. van der Werf, M.J., Overkamp, K.M. and de Bont, J.A.M. Limonene-1,2-epoxide hydrolase from Rhodococcus erythropolis DCL14 belongs to a novel class of epoxide hydrolases. J. Bacteriol. 180 (1998) 5052-5057. [PMID: 9748436]

2. Barbirato, F., Verdoes, J.C., de Bont, J.A.M. and van der Werf, M.J. The Rhodococcus erythropolis DCL14 limonene-1,2-epoxide hydrolase gene encodes an enzyme belonging to a novel class of epoxide hydrolases. FEBS Lett. 438 (1998) 293-296. [PMID: 9827564]

[EC created 2001]

Return to EC 3.3.2 home page
Return to EC 3.3 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page