Trp, LeuTrp and a number of other dipeptides
Reaction: Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on GluTrp, LeuTrp and a number of other dipeptides
Other names: aminopeptidase W; aminopeptidase X-Trp; X-Trp aminopeptidase
Comments: A glycoprotein containing Zn2+, from renal and intestinal brush border membranes
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 137010-33-4
References
1. Gee, N.S. and Kenny, A.J. Proteins of the kidney microvillar membrane. The 130kDa protein in pig kidney, recognised by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity. Biochem. J. 230 (1985) 753-764. [PMID: 4062876]
2. Gee, N.S. and Kenny, A.J. Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W. Biochem. J. 246 (1987) 97-102. [PMID: 2890346]