IUBMB Enzyme Nomenclature


Accepted name: aspartyl aminopeptidase

Reaction: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate

Comments: Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, In peptidase family M18 of aminopeptidase I

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9074-83-3


1. Kelly, J.A., Neidle, E.L. and Neidle, A. An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues. J. Neurochem. 40 (1983) 1727-1734. [PMID: 6854330]

2. Wilk, S., Wilk, E. and Magnusson, R.P. Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. 273 (1998) 15961-15970. [PMID: 9632644]

[EC created 2000]

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