IUBMB Enzyme Nomenclature


Accepted name: β-Ala-His dipeptidase

Reaction: Preferential hydrolysis of the β-AlaHis dipeptide (carnosine), and also anserine, XaaHis dipeptides and other dipeptides including homocarnosine

Other names: serum carnosinase

Comments: Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs In peptidase family M20.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 525589-43-9


1. Lenney, J.F., George, R.P., Weiss, A.M., Kucera, C.M., Chan, P.W.H. and Rinzler, G.S. Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clin. Chim. Acta 123 (1982) 221-231. [PMID: 7116644]

2. Jackson, M.C., Kucera, C.M. and Lenney, J.F. Purification and properties of human serum carnosinase. Clin. Chim. Acta 196 (1991) 193-206. [PMID: 1903095]

[EC created 1992]

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