IUBMB Enzyme Nomenclature


Accepted name: Xaa-Pro dipeptidase

Reaction: Hydrolysis of XaaPro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro

Other names: prolidase; imidodipeptidase; proline dipeptidase; peptidase D; γ-peptidase; X-Pro dipeptidase

Comments: A Mn2+-activated enzyme, In peptidase family M24 (methionyl aminopeptidase family); cytosolic from most animal tissues. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9025-32-5


1. Davis, N.C. and Smith, E.L. Purification and some properties of prolidase of swine kidney. J. Biol. Chem. 224 (1957) 261-275

2. Sjöström, H., Norén, O. and Josefsson, L. Purification and specificity of pig intestinal prolidase. Biochim. Biophys. Acta 327 (1973) 457-470. [PMID: 4778946]

3. Baksi, K. and Radhakrishnan, A.N. Purification and properties of prolidase (imidodipeptidase) from monkey small intestine. Indian J. Biochem. Biophys. 11 (1974) 7-11. [PMID: 4435812]

4. Browne, P. and O'Cuinn, G. The purification and characterization of a proline dipeptidase from guinea pig brain. J. Biol. Chem. 258 (1983) 6147-6154. [PMID: 6853481]

[EC created 1961 as EC, transferred 1972 to EC]

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