IUBMB Enzyme Nomenclature


Accepted name: dipeptidyl-peptidase II

Reaction: Release of an N-terminal dipeptide, Xaa-Yaa, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides

Other names: dipeptidyl aminopeptidase II; dipeptidyl arylamidase II; carboxytripeptidase; dipeptidyl peptidase II; dipeptidyl arylamidase II; DAP II; dipeptidyl(amino)peptidase II; dipeptidylarylamidase

Comments: A lysosomal serine-type peptidase In family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 76199-23-0


1. McDonald, J.K., Reilly, T.J., Zeitman, B.B. and Ellis, S. Dipeptidyl arylamidase II of the pituitary. Properties of lysyl-alanyl-β-naphthylamide hydrolysis: inhibition by cations, distribution in tissues and subcellular localization. J. Biol. Chem. 243 (1968) 4143-4150. [PMID: 4969969]

2. McDonald, J.K. and Schwabe, C. Intracellular exopeptidases. In Proteinases in Mammalian Cells and Tissues (Barrett, A.J. ed.), pp. 311-391 (1977) North-Holland Publishing Co, Amsterdam

[EC created 1978]

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