Xaa bond to release a C-terminal amino acid
Reaction: Cleavage of a -ProXaa bond to release a C-terminal amino acid
Other names: angiotensinase C; lysosomal carboxypeptidase C; peptidylprolylamino acid carboxypeptidase; aminoacylproline carboxypeptidase; prolyl carboxypeptidase; carboxypeptidase P; proline-specific carboxypeptidase P; PCP; lysosomal Pro-X carboxypeptidase
Comments: A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-Xaa carboxypeptidase family). Formerly EC 3.4.12.4
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9075-64-3
References
1. Walter, R., Simmons, W.H. and Yoshimoto, T. Proline specific endo- and exopeptidases. Mol. Cell. Biochem. 30 (1980) 111-127. [PMID: 6991912]
2. Odya, C.E. and Erdös, E.G. Human prolylcarboxypeptidase. Methods Enzymol. 80 (1981) 460-466. [PMID: 7341916]