IUBMB Enzyme Nomenclature


Accepted name: carboxypeptidase M

Reaction: Cleavage of C-terminal arginine or lysine residues from polypeptides

Other name(s): CPM

Comments: A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 120038-28-0


1. Skidgel, R.A. Basic carboxypeptidases: Regulators of peptide hormone activity. Trends Pharmacol. Sci. 9 (1988) 303-304. [PMID: 3074547]

2. Deddish, P.A., Skidgel, R.A. and Erdös, E.G. Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Biochem. J. 261 (1989) 289-291. [PMID: 2775217]

3. Skidgel, R.A., Davis, R.M. and Tan, F. Human carboxypeptidase M. Purification and characterization of membrane-bound carboxypeptidase that cleaves peptide hormones. J. Biol. Chem. 264 (1989) 2236-2241. [PMID: 2914904]

[EC created 1992]

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