IUBMB Enzyme Nomenclature


Accepted name: tubulinyl-Tyr carboxypeptidase

Reaction: Cleavage of the -GluTyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr

Other name(s): carboxypeptidase-tubulin; soluble carboxypeptidase; tubulin-tyrosine carboxypeptidase; tubulin carboxypeptidase; tubulinyltyrosine carboxypeptidase; tyrosinotubulin carboxypeptidase; tyrosyltubulin carboxypeptidase; TTCPase; brain I carboxypeptidase; carboxypeptidase 1; CCP1

Comments: Active at neutral pH, from brain

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 73050-23-4


1. Argaraña, C.E., Barra, H.S. and Caputto, R. Tubulinyl-tyrosine carboxypeptidase J. Neurochem. 34 (1980) 114-118. [PMID: 7452228]

2. Kumar, N. and Flavin, M. Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin. J. Biol. Chem. 256 (1981) 7678-7686. [PMID: 6114100]

3. Arce, C.A. and Barra, H.S. Association of tubulinyl-tyrosine carboxypeptidase with microtubules. FEBS Lett. 157 (1983) 75-78. [PMID: 6862022]

4. Berezniuk, I., Lyons, P.J., Sironi, J.J., Xiao, H., Setou, M., Angeletti, R.H., Ikegami, K. and Fricker, L.D. Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. J. Biol. Chem. 288 (2013) 30445-30453. [PMID: 24022482]

[EC created 1992]

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