IUBMB Enzyme Nomenclature


Accepted name: metallocarboxypeptidase D

Reaction: Releases C-terminal Arg and Lys from polypeptides

Other names: carboxypeptidase D (cattle, human, mouse, rat); gp180 (duck)

Comments: Activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase In peptidase family M14 (carboxypeptidase A family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 153967-26-1


1. Kuroki, K., Eng, F., Ishikawa, T., Turck, C., Harada, F. and Ganem, D. gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J. Biol. Chem. 270 (1995) 15022-15028.[PMID: 9525948]

2. Song, L.X. and Fricker, L.D. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J. Biol. Chem. 270 (1995) 25007-25013[PMID: 7559630]

3. Song, L.X. and Fricker, L.D. Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D. J. Biol. Chem. 271 (1996) 28884-28889[PMID: 8910535]

[EC created 1997]

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