IUBMB Enzyme Nomenclature


Accepted name: glutathione-S-conjugate glycine hydrolase

Reaction: a glutathione-S-conjugate + H2O = a [γ-glutamyl-L-cysteine]-S-conjugate + glycine

Other name(s): PCS1 (gene name); PRC1 (gene name); CPC (gene name); ATG42 (gene name); alr0975 (locus name)

Systematic name: glutathione-S-conjugate glycine hydrolase

Comments: The enzyme participates in a glutathione-mediated detoxification pathway found in plants, algae, fungi, and some bacteria. The enzymes from the plant Arabidopsis thaliana and the yeast Saccharomyces cerevisiae also catalyse the activity of EC, glutathione γ-glutamylcysteinyltransferase (phytochelatin synthase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Beck, A., Lendzian, K., Oven, M., Christmann, A. and Grill, E. Phytochelatin synthase catalyzes key step in turnover of glutathione conjugates. Phytochemistry 62 (2003) 423-431. [PMID: 12620355]

2. Grzam, A., Tennstedt, P., Clemens, S., Hell, R. and Meyer, A.J. Vacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthase. FEBS Lett. 580 (2006) 6384-6390. [PMID: 17097087]

3. Harada, E., von Roepenack-Lahaye, E. and Clemens, S. A cyanobacterial protein with similarity to phytochelatin synthases catalyzes the conversion of glutathione to γ-glutamylcysteine and lacks phytochelatin synthase activity. Phytochemistry 65 (2004) 3179-3185. [PMID: 15561184]

4. Tsuji, N., Nishikori, S., Iwabe, O., Shiraki, K., Miyasaka, H., Takagi, M., Hirata, K. and Miyamoto, K. Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120. Biochem. Biophys. Res. Commun. 315 (2004) 751-755. [PMID: 14975765]

5. Vivares, D., Arnoux, P. and Pignol, D. A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis. Proc. Natl. Acad. Sci. USA 102 (2005) 18848-18853. [PMID: 16339904]

6. Wunschmann, J., Krajewski, M., Letzel, T., Huber, E.M., Ehrmann, A., Grill, E. and Lendzian, K.J. Dissection of glutathione conjugate turnover in yeast. Phytochemistry 71 (2010) 54-61. [PMID: 19897216]

[EC created 2021]

Return to EC 3.4.17 home page
Return to EC 3.4 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page