IUBMB Enzyme Nomenclature


Accepted name: N-formylmethionyl-peptidase

Reaction: Release of an N-terminal, formyl-methionyl residue from a polypeptide

Other names: (fMet)-releasing enzyme; formylmethionine aminopeptidase

Comments: Highly specific for N-formylmethionyl peptides. Will not cleave methionyl peptides or N-formyl derivatives of amino acids other than methionine. Isolated from rat liver. Inhibited by heavy metals and activated by Cl-

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 76106-80-4


1. Suda, H., Yamamoto, K., Aoyagi, T. and Umezawa, H. Purification and properties of N-formylmethionine aminopeptidase from rat liver. Biochim. Biophys. Acta 616 (1980) 60-67. [PMID: 7437450]

[EC created 1992]

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