IUBMB Enzyme Nomenclature


Accepted name: acrosin

Reaction: Preferential cleavage: Arg, Lys

Other name(s): acrosomal proteinase; acrozonase; α-acrosin; β-acrosin; ψ-acrosin; acrosomal protease; acrosin amidase

Comments: Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9068-57-9


1. Müller-Esterl, W. and Fritz, H. Sperm acrosin. Methods Enzymol. 80 (1981) 621-632. [PMID: 7043204]

2. Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates. Biochim. Biophys. Acta 996 (1989) 89-94. [PMID: 2500154]

3. Keime, S., Adham, I.M. and Engel, W. Nucleotide sequence and exon-intron organisation of the human proacrosin gene. Eur. J. Biochem. 190 (1990) 195-200. [PMID: 2114285]

[EC created 1972]

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