IUBMB Enzyme Nomenclature


Accepted name: Lys-Lys/Arg-Xaa endopeptidase

Reaction: Cleavage of -Lys-Lys┼ and -Lys-Arg┼ bonds.

Other name(s): ASP (Aeromonas sobria)-type peptidase; Aeromonas extracellular serine protease

Comments: The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K. and Tsuge, H. Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor. J. Biol. Chem. 284 (2009) 27655-27663. [PMID: 19654332]

2. Nitta, H., Kobayashi, H., Irie, A., Baba, H., Okamoto, K. and Imamura, T. Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria. FEBS Lett 581 (2007) 5935-5939. [PMID: 18067862]

3. Kobayashi, H., Takahashi, E., Oguma, K., Fujii, Y., Yamanaka, H., Negishi, T., Arimoto-Kobayashi, S., Tsuji, T. and Okamoto, K. Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases. FEMS Microbiol. Lett. 256 (2006) 165-170. [PMID: 16487335]

4. Imamura, T., Nitta, H., Wada, Y., Kobayashi, H. and Okamoto, K. Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria. FEMS Microbiol. Lett. 284 (2008) 35-42. [PMID: 18462393]

5. Nitta, H., Imamura, T., Wada, Y., Irie, A., Kobayashi, H., Okamoto, K. and Baba, H. Production of C5a by ASP, a serine protease released from Aeromonas sobria. J. Immunol. 181 (2008) 3602-3608. [PMID: 18714034]

[EC created 2013]

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