Ile bond in factor X to form factor Xa
Reaction: Selective cleavage of ArgIle bond in factor X to form factor Xa
Other name(s): blood-coagulation factor VIIa; activated blood coagulation factor VII
Comments: Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 65312-43-8
References
1. Nemerson, Y. and Esnouf, M.P. Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor. Proc. Natl. Acad. Sci. USA 70 (1973) 310-314. [PMID: 4510277]
2. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277-318. [PMID: 367103]
3. Jackson, C.M. and Nemerson, Y. Blood coagulation. Annu. Rev. Biochem. 49 (1980) 765-811. [PMID: 6996572]
4. Broze, G.J., Jr and Majerus, P.W. Human factor VII. Methods Enzymol. 80 (1981) 228-237