and Lys bonds, including LysArg and ArgSer in (human) kininogen to release bradykinin
Reaction: Selective cleavage of some Arg and Lys bonds, including LysArg and ArgSer in (human) kininogen to release bradykinin
Other names: serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein
Comments: Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates. In peptidase family S1 (trypsin family). Formerly EC 3.4.4.21 and included in EC 3.4.21.8
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 410538-33-9
References
1. Heimark, R.L. and Davie, E.W. Bovine and human plasma prekallikrein. Methods Enzymol. 80 (1981) 157-172. [PMID: 6918767]
2. McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates. Biochemistry 20 (1981) 7196-7206. [PMID: 6976185]
3. Silverberg, M. and Kaplan, A.P. Prekallikrein. Methods Enzymol. 163 (1988) 85-95. [PMID: 3237096]
4. Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. The cDNA structure of rat plasma kallikrein. DNA 8 (1989) 563-574. [PMID: 2598771]
5. Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein. Chem. Pharm. Bull. 37 (1989) 3108-3111. [PMID: 2534361]