Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide
Reaction: Cleavage of the LeuLeu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide
Comments: A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 85270-20-8
References
1. Poe, M., Wu, J.K., Florance, J.R., Rodkey, J.A., Bennett, C.D. and Hoogsteen, K. Purification and properties of renin and γ-renin from the mouse submaxillary gland. J. Biol. Chem. 258 (1983) 2209-2216[PMID: 6337154]
2. Drinkwater, C.C., Evans, B.A. and Richards, R.I. Sequence and expression of mouse γ-renin. J. Biol. Chem. 263 (1988) 8565-8568. [PMID: 3288617]