bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Reaction: Selective cleavage at Arg bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Other names: gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afaâcytin
Comments: From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC 3.4.21.5 (thrombin).
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 104003-74-9
References
1. Pirkle, H., Theodor, I., Miyada, D. and Simmons, G. Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties and coagulant actions. J. Biol. Chem. 261 (1986) 8830-8835. [PMID: 3522580]