IUBMB Enzyme Nomenclature


Accepted name: venombin AB

Reaction: Selective cleavage at Arg bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

Other names: gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afaâcytin

Comments: From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC (thrombin).

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 104003-74-9


1. Pirkle, H., Theodor, I., Miyada, D. and Simmons, G. Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties and coagulant actions. J. Biol. Chem. 261 (1986) 8830-8835. [PMID: 3522580]

[EC created 1989]

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