> -Val
Reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala > -Val
Other names: leukocyte proteinase 3; leukocyte proteinase 4; Wegener's granulomatosis autoantigen;proteinase PR-3; proteinase-3; PMNL proteinase
Comments: From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 128028-50-2
References
1. Labbaye, C., Musette, P. and Cayre, Y.E. Wegener autoantigen and myeloblastin are encoded by a single mRNA. Proc. Natl. Acad. Sci. USA 88 (1991) 9253-9256. [PMID: 1681549]
2. Rao, N.V., Wehner, N.G., Marshall, B.C., Gray, W.R., Gray, B.H. and Hoidal, J.R. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J. Biol. Chem. 266 (1991) 9540-9548. [PMID: 2033050]
3. Brubaker, M.J., Groutas, W.C., Hoidal, J.R. and Rao, N.V. Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters. Biochem. Biophys. Res. Commun. 188 (1992) 1318-1324 [PMID: 1445363]
4. Kam, C.-M., Kerrigan, J.E., Dolman, K.M., Goldschmeding, R., von dem Borne, A.E.G.K. and Powers, J.C. Substrate and inhibitor studies on proteinase 3. FEBS Lett. 297 (1992) 119-123. [PMID: 1551417]