IUBMB Enzyme Nomenclature


Accepted name: semenogelase

Reaction: Preferential cleavage: -Tyr

Other names: prostate-specific antigen; α-seminoprotein; seminin; P-30 antigen; antigen (human clone λHPSA-1 prostate-specific protein moiety reduced); γ-seminoglycoprotein (human protein moiety reduced); γ-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced)

Comments: A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by α1-antichymotrypsin

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 110157-83-0 and 95829-41-7


1. Digby, M., Zhang, X.-Y. and Richards, R.I. Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1. Nucleic Acids Res. 15 (1989) 2137 only. [PMID: 2467258]

2. Christensson, A., Laurell, C.-B. and Lilja, H. Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur. J. Biochem. 194 (1990) 755-763. [PMID: 1702714]

[EC created 1993]

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