IUBMB Enzyme Nomenclature


Accepted name: granzyme B

Reaction: Preferential cleavage: -Asp >> -Asn > -Met, -Ser

Other names: CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase

Comments: From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 143180-74-9


1. Schmid, J. and Weissmann, C. Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139 (1987) 250-256. [PMID: 2953813]

2. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 30 (1991) 2217-2227. [PMID: 1998680]

3. Poe, M., Blake, J.T., Boulton, D.A., Gammon, M., Sigal, N.H., Wu, J.K. and Zweerink, H.J. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J. Biol. Chem. 266 (1991) 98-103. [PMID: 1985927]

[EC created 1993]

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