Reaction: Preferential cleavage with hydrophobic residues at P2, P1 and P1'
Other names: Streptococcus peptidase A; streptococcal cysteine proteinase; Streptococcus protease
Comments: From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10. Formerly EC 3.4.4.18
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9025-51-8
References:
1. Elliott, S.D. and Liu, T.-Y. Streptococcal proteinase. Methods Enzymol. 19 (1970) 252-261
2. Liu, T.-Y. and Elliott, S.D. Streptococcal proteinase. In The Enzymes, 3rd edn (Boyer, P.D., ed.), pp. 609-647 (1971) Academic Press, New York
3. Tai, J. Y., Kortt, A.A., Liu, T.-Y. and Elliott, S.D. Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain. J. Biol. Chem. 251 (1976) 1955-1959. [PMID: 1270417]
4. Lo, S.-S., Fraser, B.A. and Liu, T.-Y. The mixed disulphide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis. J. Biol. Chem. 259 (1984) 11041-11045. [PMID: 6381494]