IUBMB Enzyme Nomenclature


Accepted name: cathepsin H

Reaction: Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg bonds) as well as an endopeptidase

Other names: cathepsin B3; benzoylarginine-naphthylamide (BANA) hydrolase (obsolete); cathepsin Ba; aleurain; N-benzoylarginine-β-naphthylamide hydrolase

Comments: Present in lysosomes of mammalian cells. In peptidase family C1 (papain family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 60748-73-4


1. Barrett, A.J. and Kirschke, H. Cathepsin B, cathepsin H and cathepsin L. Methods Enzymol. 80 (1981) 535-561. [PMID: 7043200]

2. Brömme, D., Bescherer, K., Kirschke, H. and Fittkau, S. Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver. Biochem. J. 245 (1987) 381-385. [PMID: 3663163]

3. Fuchs, R., Machleidt, W. and Gassen, H.G. Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. Biol. Chem. Hoppe-Seyler 369 (1988) 469-475. [PMID: 2849458]

[EC created 1981, modified 1989]

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