EC 3.4.22.27

Reaction: Similar to cathepsin L, but with much less activity on Z-Phe-ArgNHMec, and more activity on the Z-Val-Val-Arg compound

Comments: A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 71965-46-3

References:

1. Turnek, T., Kregar, I. and Lebez, D. Acid sulphydryl protease from calf lymph nodes. Biochim. Biophys. Acta 403 (1975) 514-520. [PMID: 1182153]

2. Brömme, D., Steinert, A., Friebe, S., Fittkau, S., Wiederanders, B. and Kirschke, H. The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B. Biochem. J. 264 (1989) 475-485. [PMID: 2604727]

3. Kirschke, H., Wiederanders, B., Brömme, D. and Rinne, A. Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. Biochem. J. 264 (1989) 467-473. [PMID: 2690828]