IUBMB Enzyme Nomenclature


Accepted name: picornain 2A

Reaction: Selective cleavage of TyrGly bond in picornavirus polyprotein

Other names: picornavirus endopeptidase 2A; poliovirus protease 2A; rhinovirus protease 2A; 2A protease; 2A proteinase; protease 2A; proteinase 2Apro; picornaviral 2A proteinase; Y-G proteinase 2A; poliovirus proteinase 2A; poliovirus protease 2Apro; picornaviral 2A proteinase

Comments: From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also In peptidase family C3 (picornain 3C family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 103406-62-8


1. Bazan, J.F. and Fletterick, R.J. Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proc. Natl. Acad. Sci. USA 85 (1988) 7872-7876. [PMID: 3186696]

2. König, H. and Rosenwirth, B. Purification and partial characterization of poliovirus protease 2A by means of a functional assay. J. Virol. 62 (1988) 1243-1250. [PMID: 2831385]

3. Kräusslich, H.-G. and Wimmer, E. Viral proteinases. Annu. Rev. Biochem. 57 (1988) 701-754. [PMID: 3052288]

[EC created 1992]

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