IUBMB Enzyme Nomenclature


Accepted name: caricain

Reaction: Hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain

Other names: papaya peptidase A; papaya peptidase II; papaya proteinase ω; papaya proteinase III; papaya proteinase 3; proteinase ω; papaya proteinase A; chymopapain S; Ppω

Comments: From papaya plant, Carica papaya. In peptidase family C1 (papain family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 39307-22-7


1. Schack, P. Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme. C. R. Trav. Carlesberg 36 (1967) 67-83. [PMID: 6043136]

2. Robinson, G.W. Isolation and characterization of papaya peptidase A from commercial chymopapain. Biochemistry 16 (1975) 3695-3700. [PMID: 240390]

3. Polgár, L. Problems of classification of papaya latex proteinases. Biochem. J. 221 (1984) 555-556. [PMID: 6383350]

4. Brocklehurst, K., Salih, E., McKee, R. and Smith, H. Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase ω. Biochem. J. 228 (1985) 525-527. [PMID: 4015629]

5. Zucker, S., Buttle, D.J., Nicklin, M.J.H. and Barrett, A.J. Proteolytic activities of papain, chymopapain and papaya proteinase III. Biochim. Biophys. Acta 828 (1985) 196-204. [PMID: 3919769]

6. Dubois, T., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G. The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase ω. Biol. Chem. Hoppe-Seyler 369 (1988) 741-754. [PMID: 3063283]

[EC created 1992]

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