IUBMB Enzyme Nomenclature


Accepted name: ananain

Reaction: Hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-ArgNHMec, but broader specificity than fruit bromelain

Other name(s): stem bromelain; fruit bromelain

Comments: From stem of pineapple plant, Ananas comosus. Differs from stem and fruit bromelains in being inhibited by chicken cystatin. In peptidase family C1 (papain family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 119129-70-3


1. Rowan, A.D., Buttle, D.J. and Barrett, A.J. Ananain: a novel cysteine proteinase found in pineapple stem. Arch. Biochem. Biophys. 267 (1988) 262-270. [PMID: 3196029]

2. Rowan, A.D., Buttle, D.J. and Barrett, A.J. The cysteine proteinases of the pineapple plant. Biochem. J. 266 (1990) 869-875. [PMID: 2327970]

[EC created 1992]

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