IUBMB Enzyme Nomenclature


Accepted name: histolysain

Reaction: Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg in small molecule substrates including Z-Arg-ArgNHMec

Other names: histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase

Comments: From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 92228-52-9


1. Lushbaugh, W.B., Hofbauer, A.F. and Pittman, F.E. Entamoeba histolytica: purification of cathepsin B. Exp. Parasitol. 59 (1985) 328-336. [PMID: 2860002]

2. Luaces, A.L. and Barrett, A.J. Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica. Biochem. J. 250 (1988) 903-909. [PMID: 2898937]

[EC created 1992]

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