IUBMB Enzyme Nomenclature


Accepted name: staphopain

Reaction: Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, CASein or Z-Phe-Arg-NHMec as substrate

Other name(s): staphylopain

Comments: Known from species of Staphylococcus. Type example of peptidase family C47.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 347841-89-8


1. Hofmann, B., Hecht, H.J., Kiess, M. and Schomburg, D. Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex. Acta Crystallogr. Sect. A (Suppl.) 49 (1993) 102 only.

2. Potempa, J., Dubin, A. and Travis, J. Staphylopain. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 669-671.

3. Dubin, G., Chmiel, D., Mak, P., Rakwalska, M., Rzychon, M. and Dubin, A. Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis. Biol. Chem. 382 (2001) 1575-1582. [PMID: 11767947]

[EC created 2003]

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