IUBMB Enzyme Nomenclature


Accepted name: cruzipain

Reaction: Broad endopeptidase specificity similar to that of cathepsin L

Other name(s): congopain; cruzain; evansain; trypanopain

Comments: In peptidase family C1. Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 141588-22-9


1. Cazzulo, J.J., Stoka, V. and Turk, V. The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease. Curr. Pharm. Des. 7 (2001) 1143-1156. [PMID: 11472258]

[E created 2003]

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