, including ArgPro, but not Lys-
Reaction: Preferential cleavage: Arg, including ArgPro, but not Lys-
Other names: clostridiopeptidase B; clostridium histolyticum proteinase B; α-clostridipain; clostridiopeptidase
Comments: From the bacterium Clostridium histolyticum. It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family C11. Formerly EC 3.4.4.20
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 9028-00-6
References:
1. Mitchell, W.M. Cleavage at arginine residues by clostripain Methods Enzymol. 47 (1977) 165-170. [PMID: 927173]
2. Gilles, A.-M., Imhoff, J.-M. and Keil, B. α-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain. J. Biol. Chem. 254 (1979) 1462-1468. [PMID: 762145]
3. Gilles, A.-M., Lecroisey, A. and Keil, B. Primary structure of α-clostripain light chain. Eur. J. Biochem. 145 (1984) 469-476. [PMID: 6391922]