IUBMB Enzyme Nomenclature


Accepted name: HIV-1 retropepsin

Reaction: Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro

Other names: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease

Comments: Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 144114-21-6


1. Kuo, L.C. and Shafer, J.A. (eds) Retroviral Proteases. Methods Enzymol. 241 (1994) 1-431

2. Dunn, B.M. Human immunodeficiency virus 1 retropepsin. In: : Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D. and Woessner, J.F. eds), pp.919-928 (1998) Academic Press, London

[EC created 1992, modified 2000]

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