IUBMB Enzyme Nomenclature


Accepted name: pro-opiomelanocortin converting enzyme

Reaction: Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side

Other names: prohormone converting enzyme; pro-opiomelanocortin-converting enzyme; proopiomelanocortin proteinase; PCE

Comments: A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 80891-34-5


1. Loh, Y.P., Parish, D.C. and Tuteja, R. Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles. J. Biol. Chem. 260 (1985) 7194-7205. [PMID: 2987247]

2. Loh, Y.P. Kinetic studies on the processing of human β-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme. J. Biol. Chem. 261 (1986) 11949-11955. [PMID: 3017955]

3. Estivariz, F.E., Birch, N.P. and Loh, Y.P. Generation of Lys-γ3-melanotropin from pro-opiomelanocortin1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme. J. Biol. Chem. 264 (1989) 17796-17801. [PMID: 2553692]

[EC created 1989 as EC, transferred 1992 to EC]

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