IUBMB Enzyme Nomenclature

EC 3.4.23.30

Accepted name: pycnoporopepsin

Reaction: Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala¹⁴Leu, Tyr¹⁶Leu, and Phe²⁴Phe

Other names: proteinase Ia; Pycnoporus coccineus aspartic proteinase; Trametes acid proteinase

Comments: From the basidiomycete Pycnoporus sanguineus, formerly known as P. coccineus and Trametes sanguinea. Formerly included in EC 3.4.23.6

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 77967-78-3

References:

1. Tomoda, K. and Shimazono, H. Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme. Agric. Biol. Chem. 28 (1964) 770-773

2. Tsuru, D., Hattori, A., Tsuji, H., Yamamoto, T. and Fukumoto, J. Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis. Agric. Biol. Chem. 33 (1969) 1419-1426

3. Ichishima, E., Kumagai, H. and Tomoda, K. Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus. Curr. Microbiol. 3 (1980) 333-337

[EC 3.4.23.30 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)]

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