Reaction: Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin
Comments: Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family). Formerly EC 3.4.4.23
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9025-26-7
References:
1. Barrett, A.J. Cathepsin D and other carboxyl proteinases. In Proteinases in Mammalian Cells and Tissues (Barrett, A.J., ed.) p. 209-248 (1977) North-Holland Publishing Co, Amsterdam.
2. Takahashi, T. and Tang, J. Cathepsin D from porcine and bovine spleen. Methods Enzymol. 80 (1981) 565-581. [PMID: 7341918]
3. Faust, P.L., Kornfeld, S. and Chirgwin, J.M. Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Natl. Acad. Sci. USA 82 (1985) 4910-4914. [PMID: 3927292]
4. Conner, G.E. Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme. Biochem. J. 263 (1989) 601-604. [PMID: 2512908]