IUBMB Enzyme Nomenclature


Accepted name: envelysin

Reaction: Hydrolysis of proteins of the fertilization envelope and dimethylcasein

Other names: sea-urchin-hatching proteinase; hatching enzyme; chorionase; chorion-digesting proteinase; chymostrypsin; sea urchin embryo hatching enzyme

Comments: A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 50812-13-0


1. Barrett, D. and Edwards, B.F. Hatching enzyme of the sea urchin Strongylocentrotus purpuratus. Methods Enzymol. 45 (1976) 354-373. [PMID: 1012003]

2. Lepage, T. and Gache, C. Purification and characterization of the sea urchin embryo hatching enzyme. J. Biol. Chem. 264 (1989) 4787-4793. [PMID: 2925668]

3. Lepage, T. and Gache, C. Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo. EMBO J. 9 (1990) 3003-3012. [PMID: 2167841]

4. Nomura, K., Tanaka, H., Kikkawa, Y., Yamaguchi, M. and Suzuki, N. The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family. Biochemistry 30 (1991) 6115-6123. [PMID: 1711895]

[EC created 1978]

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